As a core hub of Chinas biopharmaceutical industry，Shanghai，while leading in industrial scale and innovation strength，faces the dilemma of talent loss. Based on the “immigrant health effect”，this paper comprehensively utilizes methods such as online data mining，surveys，and model building to deeply analyze this issue. The study finds that talent mobility in Shanghai’s biopharmaceutical industry exhibits a pattern of “high-end clustering and mid-end loss”. Health depletion is a key driving factor of talent loss，and the moderating effect of corporate health investment is significant. Generational and positional differences impose varying requirements on health management strategies. To address this，the article proposes coping strategies from three levels：enterprises building a “health-development” integration mechanism，the government creating a “health-first” policy ecosystem，and society constructing a multi-stakeholder collaborative support network. It also recommends establishing a special fund and incorporating a “talent health index” into park assessments.