New infrastructure has become an important support for China’s economic transformation and a cornerstone for comprehensive improvement and upgrading of regional production，living，and ecological aspects. In order to examine the development level，temporal evolution，spatial differences and driving factors of new infrastructure，this research constructs a comprehensive evaluation index of new infrastructure development level based on the relevant data of the three major city clusters of Beijing-Tianjin-Hebei，Yangtze River Delta and Chengdu-Chongqing Economic Circle from 2013 to 2022，uses the TOPSIS-entropy method and multiple linear regression model to analyze the comprehensive measurement and driving factors. The research findings three conclusions.（1）Over the past decade，the overall level of new infrastructure development in the three city clusters has shown an increasing trend，while the gap in development level has gradually narrowed.（2）There is spatial heterogeneity within and between regions，with the development level of the three city clusters being significantly higher than other provinces and cities. The development focus is mainly concentrated in the Yangtze River Delta and Chengdu-Chongqing Economic Circle，particularly in Jiangsu and Sichuan provinces.（3）The level of new infrastructure development is influenced by various driving factors，including the level of urban economic development，the level of highly integrated industrial structure，the level of industrial agglomeration，the level of urban financial development，the level of urbanization，and the size of population，which are key driving factors. Path planning can be carried out from the aspects of economic stimulation，industrial adaptation，urban-rural integration，tailored approaches，and responsibility adaptation，construct a comprehensive and coordinated regional governance mechanism，continuously optimize and improve the hierarchical construction types，narrow the gap between regions，and achieve regional common prosperity guided by new infrastructure.