一种新型磁性生物贴片的性质

doi:10.12066/j.issn.1007-2861.1961

上海大学学报(自然科学版) ›› 2019, Vol. 25 ›› Issue (5): 767-775.doi: 10.12066/j.issn.1007-2861.1961

一种新型磁性生物贴片的性质

杨凯, 裴宁(), 王琦鑫, 蔡兰兰

上海大学理学院, 上海 200444

收稿日期:2017-06-05 出版日期:2019-10-30 发布日期:2019-10-31
通讯作者: 裴宁 E-mail:pn@shu.edu.cn
基金资助:
国家自然科学基金资助项目(11304194)

Properties of a new magnetic biological patch

Kai YANG, Ning PEI(), Qixin WANG, Lanlan CAI

College of Sciences, Shanghai University, Shanghai 200444, China

Received:2017-06-05 Online:2019-10-30 Published:2019-10-31
Contact: Ning PEI E-mail:pn@shu.edu.cn

摘要/Abstract

摘要：

针对可植入性磁靶向治疗, 设计并制备出了一种新型的、无毒的磁性生物贴片, 并对贴片的结构、性质进行了研究. 体外实验研究发现, 当磁性生物贴片置于匀强磁场中时, 磁性生物贴片能有效地将氧化铁颗粒吸附在贴片的周围. 针对磁性生物贴片距流体的距离以及外加磁场的磁感应强度对贴片吸附氧化铁颗粒的影响规律进行了实验测试, 发现磁性生物贴片吸附氧化铁颗粒的量, 随贴片与流体间的距离的增加而减少, 随外加磁场的磁感应强度的增大呈现先增多后减少的规律. 最后, Ansys软件模拟的计算结果对实验规律给出了合理解释.

关键词: 磁靶向治疗, 有限元分析, 磁性生物贴片, 磁感应强度

Abstract:

A new non-toxic magnetic biological patch had been designed for implant assisted-magnetic drug targeting. The structure and properties of the MBP were characterized. In vitro experimental results showed that the ferric oxide particles could be captured effectively around MBP when it was placed in the uniform magnetic field. Effects of the distance between fluid and MBP, and magnetic flux density on the accumulation of the ferric oxide particles attracted by MBP were investigated in vitro. Accumulation of ferric oxide particles decreased rapidly with the increasing distance between fluid and MBP. Accumulation of ferric oxide particles first increased and then decreased with increment of magnetic flux density of the uniform magnetic field. Experiment results were explained by numerical analysis using Software Ansys.

Key words: magnetic targeting, finite-element analysis, magnetic biological patch, magnetic flux density

中图分类号:

O469

杨凯, 裴宁, 王琦鑫, 蔡兰兰. 一种新型磁性生物贴片的性质[J]. 上海大学学报(自然科学版), 2019, 25(5): 767-775.

Kai YANG, Ning PEI, Qixin WANG, Lanlan CAI. Properties of a new magnetic biological patch[J]. Journal of Shanghai University（Natural Science Edition）, 2019, 25(5): 767-775.

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一种新型磁性生物贴片的性质

Properties of a new magnetic biological patch

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